Technologies
Pipelines
Locate Us
- UB. ONE, 81 UBI AVENUE 4, #05-21, Singapore 408830
- info@pantheralabs.co
OSTEOCARE
A serious and growing healthcare problem with an increasing aging population
Bone Disorder
Decreased bone mass and qualitative change in the bone micro-architecture associated with increased fracture risk are characteristics of osteoporosis. The major complication of osteoporosis is osteoporotic fractures that result in limited ambulation, chronic pain, loss of independency and low quality of life, which eventually increases the risk of mortality.
Causes of osteoporosis
- Decreased MSCs in bone tissue due to homing disorder
- Less mature osteoblasts as a result of impaired osteogenic ability of MSCs
- Imbalance of osteoblasts and osteoclasts aggravated by the senescence of MSCs.
- Immune disorders in the bone niche caused by abnormal activation of immune cells and impaired immunoregulatory ability of MSCs.
Damaged Joint
Eighty-five percent of osteoarthritis cases are in the knee, followed by the hand and hip. One major cause of OA is obesity with excess weight loading pressure on weight-bearing joints. Abnormal loading of cartilage eventually causes damage to the cartilage matrix and triggers inflammation.
MSC-based therapy initiates repair process
MSC transplantation into the bone tissue and joint has treatment potential for osteoporosis4 and OA5 albeit limited efficacy. With Panthera Labs’ early passage MSCs and aided by the proprietary formulation of MEV-Ob (for osteoporosis) and MEV-Cho (for OA) to enhance the restoration process, we believe our treatment aims can be achieved to improve the quality of life for patients.
Treatment Aims
| Osteoporosis | Osteoarthritis |
|---|---|
| Increase bone density | Slow joint destruction |
| Repair fractures | Restore cartilage |
| Reduce pain | Reduce pain |
| | Improve mobility function |
Development Stages for
Osteocare
Osteocare
References
- Hanser D, Pelizzari P, Pyenson B. Medicare cost of osteoporotic fractures – 2021 updated report. Milliman Research Report. 2021;p1-44.
- https://www.boneandjointburden.org/fourth-edition/iiib10/osteoarthritis
- Salamanna F, Maglio M, Sartori M, Tschon M, Fini M. Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence. Int J Mol Sci. 2020;21(5):1762.
- Fakhry M, Hamade E, Badran B, Buchet R, Magne D. Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells. 2013;5(4):136-148.
- Somoza RA, Welter JF, Correa D, Caplan AI. Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations. Tissue Eng Part B Rev. 2014;20(6):596-608.